Antigen quantification asin vitroalternative for potency testing of inactivated viral poultry vaccines
نویسندگان
چکیده
منابع مشابه
Inactivated Viral Vaccines
The first report of “virus” inactivation for vaccine purposes was described in 1886 when Daniel Elmer Salmon and Theobald Smith immunized pigeons with what they thought was a heat-killed hog cholera “virus” (Salmon and Smith 1886). Although in reality it was a cholera-like bacterium, it seeded the scientific community with evidence that immunization with inactivated pathogens can provide protec...
متن کاملProper Use of Inactivated Poultry Vaccines
I nactivated vaccines now are commonly-used tools to stimulate the immune systems of layers and breeders. For viral antigens, inactivated vaccines are used primarily to induce a prolonged antibody response in birds which have previously received live virus vaccines. For bacterial antigens, these vaccines are typically used in birds which have not previously been vaccinated with a live bacterial...
متن کاملValidation of alternative methods for the potency testing of vaccines.
This is the report of the thirty-first of a series of workshops organised by the European Centre for the Validation of Alternative Methods (ECVAM). ECVAMs main goal, as defined in 1993 by its Scientific Advisory Committee, is to promote the scientific and regulatory acceptance of alternative methods which are of importance to the biosciences and which reduce, refine or replace the use of labor...
متن کاملRabies Vaccines for Human Use: Potency Testing Without Mouse Challenge?
215 Rabies vaccines for human use currently are tested for potency by a mouse challenge assay. this test was developed by the National Institutes of Health (NIH) and is therefore referred to as the NIH test. Its origins go back to the 1950’s, well before good manufacturing practice (GMP) was established. the NIH test soon was recognized to be highly variable, to consume a large number of animal...
متن کاملHigh resolution identity testing of inactivated poliovirus vaccines
BACKGROUND Definitive identification of poliovirus strains in vaccines is essential for quality control, particularly where multiple wild-type and Sabin strains are produced in the same facility. Sequence-based identification provides the ultimate in identity testing and would offer several advantages over serological methods. METHODS We employed random RT-PCR and high throughput sequencing t...
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ژورنال
عنوان ژورنال: Veterinary Quarterly
سال: 2000
ISSN: 0165-2176,1875-5941
DOI: 10.1080/01652176.2000.9695063